They can also block your works, your inspirations and "luck" in this field when you take a path of darkness, or simply when you begin to loosen your spirituality for something like a "puffery".
I personnaly don't like very much soccer, but analogically it is very intersting to compare this sport with Alchemy.
Everybody in the field play the game and they all want to put the goal. In fact they shoot the ball randomly, but generally they miss the goal. Sometime a referee stop you or give you a yellow or red card because of your bad behavior, you can be excluded of the field.
It is the same thing in Alchemy.
For those who are lost, lost because, not of ignorance, but because of the darkness in their heart, there is no hope for them. They'll be bloked. They'll be stopped and excluded.
And it's all of their fault.